PDGF Receptor Alpha (PDGFRα) Mutations in GIST
نویسنده
چکیده
PDGF is expressed in variable levels in normal human tissues and organs. For instance, the highest expression of PDGF-A is found in the heart, skeletal muscle and pancreas. PDGF-B is expressed with the highest amounts in the heart and placenta, and moderate levels in other organs. PDGF-C is expressed with high levels in the heart, kidney, adrenal gland, and pancreas, and low levels in liver and ovary. No expression of PDGF-C can be detected in spleen or colon. The highest expression of PDGF-D is found in the heart, pancreas, and ovary and no detectable expression in the brain, lung and skeletal muscle.
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تاریخ انتشار 2011